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As a PDE5 inhibitor, Vardenafil works by relaxing the blood vessels in the penis, allowing for increased blood flow. This helps men with erectile dysfunction (ED) achieve and maintain an erection during sexual arousal. It works by blocking the action of the enzyme phosphodiesterase type 5 (PDE5), which normally breaks down cyclic GMP, a substance that helps relax the smooth muscles in the penis and enables blood flow.

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